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膳食纤维摄入可降低结直肠腺癌风险:meta分析

Dietary fiber intake reduces risk for colorectal adenoma: A meta-analysis

来源:Scopus 发布时间:2014-7-16
作者:Ben, Q., Sun, Y., Chai, R., Qian, A., Xu, B., Yuan, Y.
机构: 上海交通大学医学院附属瑞金医院消化内科
期刊: GASTROENTEROLOGY 2014年3月3期146卷

Abstract
Background & Aims Reports on the association between dietary fiber intake and risk of colorectal adenoma (CRA), the precursor of colorectal cancer, have been inconsistent. We conducted a meta-analysis of case-control and cohort studies to analyze this association. Methods We searched the MEDLINE and EMBASE databases to identify relevant studies published through July 2013. A random-effects model was used to estimate summary relative risks (SRRs) and 95% confidence intervals (CIs) for associations between fiber intake and CRA risk. Heterogeneity among studies was assessed using the Cochran Q and I2 statistics. Results Our meta-analysis included 20 studies involving 10,948 subjects with CRA. The SRRs of CRA for total dietary fiber were 0.72 (95% CI, 0.63-0.83) in a high- vs low-intake analysis and 0.91 (95% CI, 0.87-0.95) per 10-g/day increase in fiber intake in a dose-response model. Subgroup analyses indicated a significant inverse association between total fiber intake and CRA risk in case-control studies (SRR, 0.66; 95% CI, 0.56-0.77), but not in cohort studies (SRR, 0.92; 95% CI, 0.76-1.10). The SRRs of CRA were 0.84 for fruit fiber (95% CI, 0.76-0.94; n = 6 studies), 0.93 for vegetable fiber (95% CI, 0.84-1.04; n = 6 studies), and 0.76 for cereal fiber (95% CI, 0.62-0.92; n = 9 studies) in high- vs low-intake analyses. Conclusions Our findings support the hypothesis that high dietary fiber intake is associated inversely with CRA risk. Further studies with prospective designs that use validated questionnaires and control for important confounders are warranted. 

通讯作者:Yuan, Y.; Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai 200025, China;
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